Livedoid vasculitis - Livedoidalne Zapalenie Naczyń
Livedoidalne Zapalenie Naczyń (Livedoid vasculitis) to przewlekła choroba skóry, występująca głównie u kobiet w młodym i średnim wieku. Jednym z akronimów opisujących jego cechy jest „Bolesne plamicowe owrzodzenia z siateczkowym wzorem na kończynach dolnych” (FIOLETOWY). Jest to związane z wieloma chorobami, w tym z przewlekłym nadciśnieniem żylnym i żylakami.
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Może towarzyszyć ból.
References
Livedoid vasculopathy to rzadka choroba skóry charakteryzująca się bolesnymi owrzodzeniami, które nawracają na podudziach.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy to rzadka choroba skóry powodująca nawracające owrzodzenia na podudziach, pozostawiające blade blizny zwane atrofią blanszową. Chociaż dokładna przyczyna jest nadal niejasna, uważa się, że głównym czynnikiem jest zwiększone krzepnięcie krwi (hypercoagulability) , a stan zapalny odgrywa drugorzędną rolę. Czynniki przyczyniające się do krzepnięcia obejmują: deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. W biopsjach stan ten wykazuje skrzepy krwi w naczyniach, pogrubienie ścian naczyń i blizny. Leczenie obejmuje wielotorowe podejście, skupiające się na zapobieganiu tworzeniu się zakrzepów krwi za pomocą leków, takich jak leki przeciwpłytkowe, leki rozrzedzające krew i terapia fibrynolityczna. Na tę chorobę skóry można stosować różne leki - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy to rzadki stan, w którym zmiany chorobowe występują na obu nogach. Uważa się, że powstawanie skrzepów krwi w drobnych naczyniach krwionośnych jest spowodowane zwiększonym krzepnięciem i zmniejszonym rozpadem skrzepów, a także uszkodzeniem wyściółki naczyń. Częściej występuje u kobiet, zwłaszcza w wieku od 15 do 50 lat. Skuteczne okazało się rzucenie palenia, opatrywanie ran i stosowanie leków, takich jak leki rozrzedzające krew i leki przeciwpłytkowe.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
